Non-alcoholic fatty liver disease: Unexplained weight loss is a symptom – how much though?


In a study with the National Library of Health, unexplained weight loss as a symptom of NAFLD was investigated.

The study analysed six patients who developed severe hepatic dysfunction following rapid weight loss or malnutrition.

Rapid weight loss was defined as an 18 to 91 kg loss.

Four patients either died or received an urgent liver transplant.

The study noted: “The mechanism of liver injury in aggressive steatohepatitis is unknown, but rapid fat mobilisation in obese patients may potentially cause oxidative stress to the liver and further study is needed to determine if there is a genetic predisposition to this form of injury and if antioxidants may protect the liver during rapid weight loss/malnutrition.”


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