And there was certainly no problem with Kane’s positioning when the South Korea international whipped in a cross from the left, only for John Ruddy to tip the England striker’s header just over the bar.
Tottenham had a let-off late on when Ruben Neves’ dipping shot hit the crossbar, with the midfielder’s free-kick deflected over just a few minutes later.
Son tried to carve out a couple more chances to no avail, with the game ultimately heading towards penalties.
And perhaps boosted by his first-half goal, Kane confidently despatched his spot-kick to get the penalty shoot-out off to the perfect start for Spurs.
Sergio Reguilon and Bryan Gil also scored, and while Pierre-Emile Hojbjerg saw his spot-kick saved by Ruddy, ultimately it didn’t matter.
Pierluigi Gollini saved Dendoncker’s kick in between misses from Neves and Conor Coady as Nuno’s side secured their place in the last 16, where they’ll face a trip to Burnley – with Kane now happily back on the goal trail.